Charles Chadwyck-Healey founded the Chadwyck-Healey publishing group in 1973. Chadwyck-Healey published research material in the humanities and social sciences on microfilm, CD-Rom and on the internet, bought by university, public and national libraries throughout the world. He sold the group of companies which included Chadwyck-Healey Ltd, Cambridge; Chadwyck-Healey Inc., Alexandria, Virginia; and Chadwyck-Healey Espana SL, Madrid to Proquest, in Ann Arbor, Michigan in 1999. Proquest continue to use ‘Chadwyck-Healey’ as a brand name and their operation outside the US is still based in Cambridge, UK.

See Proquest website.

In 1989 Chadwyck-Healey founded Eriis (the Environmental Risk Information and Imaging Service) later renamed GeoSure which was sold successfully in 1999, and he was also one of the founding partners in MicroPatent in New Haven, Connecticut which published patent information on CD-Rom and on the internet and was sold successfully in 1997.

He was a member of the Library and Information Commission 1995-2000; and the Marshall Aid Commemoration Commission 1994-2000. He is an Honorary Fellow of Trinity College, Oxford.

In retirement he was the first chairman of openDemocracy Ltd 2001-2004; High Sheriff of Cambridgeshire 2004-2005; Deputy Lieutenant of Cambridgeshire 2004-; and chairman of the Wildlife Trust of Bedfordshire, Cambridgeshire, and Northamptonshire 2009-2013.